Short communication COMPARATIVE ALLOMETRIC ANALYSIS OF THREE ISOXAZOLYLPENICILLINS IN FOUR MAMMALIAN SPECIES
نویسندگان
چکیده
Comparative allometric analysis of selected pharmacokinetic parameters of cloxacillin, dicloxacillin and flucloxacillin in four animal species (cats, dogs, pigs and sheep) was performed. The correlations between the total body clearance (CLB) and the volume of distribution (Vdarea) to the body weight of animals were established. They can be expressed by the equations: cloxacillin − CLB =5.68W , Vdarea=0.24W ; dicloxacillin − CLB=17.95W , Vdarea=2.93W ; and flucloxacillin − CLB=10.59W , Vdarea=1.52W . No statistically significant correlation was found for the half-life values.
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